刘成伟教授，博士生导师
联系方式：
E-mail:liuchw@nefu.edu.cn
地址：黑龙江省哈尔滨市香坊区和兴路26号
澳门银银河7163(新逸夫教学楼) 617房间
工作及教育经历:
2009/11 ~至今澳门银银河7163 教授
2015/11 ~ 2019/09北海道大学大学院理学研究院化学部门助理教授
2014/04 ~ 2015/10日本北海道大学大学院理学研究院化学部门博士后
2011/04 ~ 2014/03日本北海道大学,综合化学院博士
2009/04 ~ 2011/03日本秋田县立大学,生物资源研究科硕士
2008/03 ~ 2009/03日本秋田县立大学,生物资源研究科研究生
2004/08 ~ 2008/02东阳光集团制药部门研究员
专业特长:
合成生物学，天然产物化学，次级代谢产物生物合成途径解析，异源合成。
研究经验和研究领域:
植物，微生物生产的天然产物是重要的医药资源，为人类的健康做出了巨大的贡献，本课题组主要研究内容是天然产物的生物合成途径解析。通过基因组编辑技术（CRISPR/Cas9）和米曲霉异源表达的方法，对具有生理活性物质的生物合成途径进行分析，解明酶促反应机理。探索和激活具有潜在功能的基因，挖掘新的天然产物。并且通过基因编辑以及异源表达等方法，高效生产具有应用价值的化合物。研究内容主要归纳为以下几个方向：
研究方向一：大型真菌（蘑菇）次级代谢产物的生物合成途径解析：
许多蘑菇菌类具有广泛的医用价值，比如自古以来就被用于中药药材的灵芝，桑黄等，具有解毒，活血，增强免疫力，抗衰老等功效。但具有这些功效的天然产物还没有完全被确定，这是由于蘑菇对栽培条件要求苛刻，基因操作困难，导致蘑菇菌类生产的天然产物的生物合成研究相对匮乏。我们最近应该米曲霉表达系统，成功解明了猴头菇生产的猴头菌素（erinacine）的生物合成途径。在此基础上将继续对有应用价值的大型真菌生产的天然产物生物合成途径进行研究。
研究方向二：激活具有潜在功能基因，挖掘新化合物：
近年来，随着基因组技术的发展，必要的基因组信息可以在短时间内获得。通过这些信息可以清楚地看到，存在于微生物中的许多次级代谢产物生物合成基因的转录活性受到了抑制。例如，丝状真菌Aspergillus flavus的全基因组中预测存在30种以上次级代谢产物生物合成基因簇，但实际上只有少数几种被识别。在许多情况下，大多数生物合成基因处于休眠状态，并不能确认生产天然产物。通过异源表达方式，不仅可以解明已知天然产物的生物合成途径，还可以通过激活具有潜在功能的基因簇，挖掘新的代谢产物。
研究方向三：高效合成具有应用价值的化合物：
“合成生物学”理论和技术极大的推动了生物技术领域的发展，被意为可改变世界的十大新技术之一，是影响未来的颠覆性技术，极大的促进了生物制造领域的创新发展。通过我们对基因的挖掘，明确酶的功能和反应机理，将来可以定向的对酶进行改造，将不同来源的生物相关代谢途径模块化，并在底盘上进行组装，设计合适的生物合成路径，提高代谢途径的效率，降低大规模生物催化反应的成本，实现各种重要次级代谢产物高效生物合成和规模化生产。
教学情况:
主讲本科生《微生物学》、《科学道德》；研究生《合成生物学》、《高级微生物学专题》等课程。
近年承担的主要课题:
1.国家自然科学基金面上项目(主持):猴头菌酮类大型真菌杂萜的生物合成途径解析及其异源重构（32370069, 2024.01~2027.12）；
2.国家自然科学基金区域创新发展联合基金重点支持项目(子课题负责人):基于“活性机制-资源评价-代谢合成”的寒地道地药材稀有皂苷应用基础研究(U22A20369, 2023.01~2026.12)；
3.黑龙江省自然科学基金联合引导项目(主持):吲哚二萜类化合物环化机理与多样性形成机制的研究（LH2023C035, 2023.07~2026.07）；
4.山东省自然科学基金重点项目(参与)：抗阿尔茨海默药物先导化合物的异源生物合 成与作用机理研究(ZR2021LSW022, 2022.01~2024.12)；
5.校企联合横向课题(主持)，胞磷胆碱钠及核苷酸原料酶法生产工艺开发,（HKF220150002，2022.04~2023.04）;
6.日本学术振兴会青年基金(主持),蘑菇类生产的医药候补品萜类化合物生产法的开发(18K14342, 2018.04 ~ 2020.03);
7.日本学术振兴会青年基金B(主持),吲哚二萜类天然化合物生物合成过程中多样性形成 的机理和调控解析(16K16636, 2016.04 ~ 2018.03)
主要发表文章: (*为通讯作者)
2024年
1.Jianzhao Qi, Jing Wu, Shi-jie Kang, Jing-ming Gao, Hirokazu Kawagishi, Hongwei Liu,Chengwei Liu*.
The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genusHericium: A review.Chin J Nat Med.2024,22(0): 1-24. doi:10.1016/S1875-5364(24)60590-X.
2.Jian-zhao Qi, Shi-jie Kang, Ling Zhao, Jin‑ming Gao &Chengwei Liu*.
Natural and engineered xylosyl products from microbial source.Nat. Prod. Bioprospect.2024, 14, 13. doi.org/10.1007/s13659-024-00435-1.
3.Yang, Hui, Chaonan Song,Chengwei Liu*, and Pengchao Wang*.
Synthetic Biology Tools for Engineering Aspergillus oryzae.J. Fungi.2024, 10,34. doi.org/10.3390/jof10010034.
2023年
4.Liqiu Zhang, Meixia Yan &Chengwei Liu*.
A comprehensive review of secondary metabolites from the genusAgrocybe: Biological activities and pharmacological implications.Mycology.2023. DOI: 10.1080/21501203.2023.2292994.
5.Ji-Shuang Qi, Yingce Duan, Zhao-Chen Li, Jin-Ming Gao, Jianzhao Qi*,Chengwei Liu*.
The alkynyl-containing compounds from mushrooms and their biological activities.Nat Prod Bioprospect.2023,13(1),50. doi: 10.1007/s13659-023-00416-w.
6.Haiyan Han, Chunyan Yu, Jianzhao Qi, Pengchao Wang, Peipei Zhao, Wenbing Gong, Chunliang Xie, Xuekui Xia*,Chengwei Liu*.
High-efficient production of mushroom polyketide compounds in a platform host Aspergillus oryzae.Microb Cell Fact.2023,22, 60. doi: 10.1186/s12934-023-02071-9.
7.Jianzhao Qi, Yu-Qi Gao, Shi-Jie Kang,Chengwei Liu*, Jin-Ming Gao*.
Secondary Metabolites of Bird's Nest Fungi: Chemical Structures and Biological Activities.J Agric Food Chem.2023,71, 6513-6524.doi: 10.1021/acs.jafc.3c00904.
8.Chunyan Yu#, Jianzhao Qi#, Haiyan Han, Pengchao Wang*,Chengwei Liu*.
Progress in pathogenesis research of Ustilago maydis, and the metabolites involved along with their biosynthesis.Mol Plant Pathol.2023 Feb 17. doi: 10.1111/mpp.13307.
9.Jingwen Niu, Jianzhao Qi, Pengchao Wang,Chengwei Liu*, Jin-Ming Gao*.
The chemical structures and biological activities of indole diterpenoids.Nat Prod Bioprospect.2023, 13(1), 3. doi: 10.1007/s13659-022-00368-7.
10.Cha Cao, Dengfan Lin, Yingjun Zhou, Na Li, Yiwen Wang, Wenbeng Gong, Zuohua Zhu,Chengwei Liu, Li Yan, Zhenxiu Hu, Yuande Peng, Chunliang Xie*.
Solid-state fermentation of Apocynum venetum L. by Aspergillus niger: Effect on phenolic compounds, antioxidant activities and metabolic syndrome-associated enzymes.Front Nutr.2023, 10:1125746. doi: 10.3389/fnut.2023.1125746.
11.周一鸣，祁建钊，段应策，赵敏,刘成伟*.
大型担子菌中二萜化合物生物合成研究进展.《菌物学报》,2023,44(1):101-117. doi: 10.13346/j.mycosystema.220374
2022年
12.Yingce Duan, Jianzhao Qi, Jin-Ming Gao,Chengwei Liu*.
Bioactive components of Laetiporus species and their pharmacological effects.
Appl Microbiol Biotechnol.2022, 106(18):5929-5944.doi: 10.1007/s00253-022-12149-w.
13.Yingce Duan, Haiyan Han, Jianzhao Qi, Jin-Ming Gao, Zhichao Xu, Pengchao Wang, Jie Zhang,Chengwei Liu*.
Genome sequencing of Inonotus obliquus reveals insights into candidate genes involved in secondary metabolite biosynthesis. BMC Genomics.2022，23(1):314. doi: 10.1186/s12864-022-08511-x.
14.Ping Zhang, Jianzhao Qi, Yingce Duan, Jin-Ming Gao*,Chengwei Liu*.
Research Progress on Fungal Sesterterpenoids Biosynthesis.J. Fungi.2022，8(10), 1080; https://doi.org/10.3390/jof8101080.
15.Jiajun Wu, Xiaoran Yang, Yingce Duan, Pengchao Wang, Jianzhao Qi, Jin-Ming Gao,Chengwei Liu*.
Biosynthesis of Sesquiterpenes in Basidiomycetes: A Review.J. Fungi.2022，8(9), 913; https://doi.org/10.3390/jof8090913.
16.Jianzhao Qi, Haiyan Han, Dan Sui, Shengnan Tan, Changli Liu, Pengchao Wang, Chunliang Xie, Xuekui Xia, Jin-ming Gao*,Chengwei Liu*.
Efficient production of a cyclic dipeptide (cyclo-TA) using heterologous expression system of filamentous fungus Aspergillus oryzae.Microb Cell Fact.2022，21(1):146. doi: 10.1186/s12934-022-01872-8.
17.Pengchao Wang, Xiwen Zhang, Yucheng Tao, Xubing Lv, Shengjie Cheng,Chengwei Liu*.
Improved l-phenylglycine synthesis by introducing an engineered cofactor self-sufficient system.Synth Syst Biotechnol.2022, 7(1):513-521. doi: 10.1016/j.synbio.2021.12.008.
18.Rui-qi Zhang; Xi-long Feng; Zhen-xin Wang; Tian-chen Xie; Yingce Duan;Chengwei Liu; Jin-ming Gao; Jianzhao Qi
Genomic and Metabolomic Analyses of the Medicinal Fungus Inonotus hispidus for Its Metabolite’s Biosynthesis and Medicinal Application.J. Fungi.2022，8(12), 1245; https://doi.org/10.3390/jof8121245.
19.Chunlei Wang, Sijia Wang, Jieru Zhang, Shumin Jiang, Daizong Cui, Haiqiong Sun,Chengwei Liu, Lili Li, Min Zhao*.
The Biodegradation of Indigo Carmine by Bacillus safensis HL3 Spore and Toxicity Analysis of the Degradation Products.Molecules2022, 27(23), 8539;https://doi.org/10.3390/molecules27238539.
20.Lan Jiang, Kangjie Lv, Guoliang Zhu, Zhi Lin, Xue Zhang, Cuiping Xing, Huanting Yang, Weiyan Zhang, Zhixin Wang,Chengwei Liu, Xudong Qu, Tom Hsiang, Lixin Zhang, Xueting Liu*.
Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cell Aspergillus oryzae.Synth Syst Biotechnol.2022, 23, 7(4), 1142-1147.doi:10.1016/j.synbio.2022.08.002.
21.Lan Jiang, Huanting Yang, Xue Zhang, Xiaoying Li, Kangjie Lv, Weiyan Zhang, Guoliang Zhu,Chengwei Liu, Yongheng Wang, Tom Hsiang, Lixin Zhang, Xueting Liu*.
Schultriene and nigtetraene: two sesterterpenes characterized from pathogenetic fungi via genome mining approach.Appl Microbiol Biotechnol.2022, 106(18):6047-6057.doi: 10.1007/s00253-022-12125-4.
22.Zhenxin Wang, Xilong Feng,Chengwei Liu, Jinming Gao, Jianzhao Qi*.
Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus.Antibiotics2022,11(8):1097.doi: 10.3390/antibiotics11081097.
23.韩海燕,段应策,彭爽,祁建钊,刘成伟*
炭角菌属次生代谢产物及药理活性研究进展
《世界科学技术-中医药现代化》,2022, DOI：10.11842/wst.20211109005
24.朱玥彤,高绪卿,李一冰,安百强,段应策,刘成伟*.
虎乳灵芝活性成分及药理作用研究进展
《世界中医药》,2022,17(13):1846-1851.DOI：10.3969/j.issn.1673-7202.2022.13.009
25.段应策,隋丹,汪麟,张肖宁,汪春蕾,刘成伟*
桦褐孔菌小分子化合物化学成分及其药用价值的研究进展
《菌物研究》,2022,20(03):214-227. doi: 10.13341/j.jfr.2021.1451.
2021年
26.Kaho Sogahata, Taro Ozaki, Yuya Igarashi, Yuka Naganuma,Chengwei Liu, Atsushi Minami, Hideaki Oikawa*.
Biosynthetic Studies of Phomopsins Unveil Posttranslational Installation of Dehydroamino Acids by UstYa Family Proteins.Angew Chem Int Ed Engl.,2021,60 (49), 25729-25734. doi: 10.1002/anie.202111076.
27.Yulu Jiang, Taro Ozaki,Chengwei Liu, Yuya Igarashi, Ying Ye, Shoubin Tang, Tao Ye, Jun-Ichi Maruyama, Atsushi Minami, Hideaki Oikawa*.
Biosynthesis of Cyclochlorotine: Identification of the Genes Involved in Oxidative Transformations and Intramolecular O, N-Transacylation.Org Lett.,2021, 23 (7), 2616-2620. doi: 10.1021/acs.orglett.1c00525.
28.Lan Jiang, Xue Zhang, Yuya Sato, Guoliang Zhu, Atsushi Minami, Weiyan Zhang, Taro Ozaki, Bin Zh, Zhixin Wang, Xinye Wang, Kangjie L, Jingyu Zhang, Yongheng Wang, Shushan Gao,Chengwei Liu, Tom Hsiang, Lixin Zhang, Hideaki Oikawa*, Xueting Liu*.
Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases.Org Lett.,2021, 23 (12), 4645-4650. doi: 10.1021/acs.orglett.1c01361.
29.Changli Liu, Xiaotong Wang, Hongyi Yang,Chengwei Liu, Zhi Zhang, Guoqiang Chen
Biodegradable polyhydroxyalkanoates production from wheat straw by recombinant Halomonas elongata A1.Int J Biol Macromol. 2021, 187, 675-682. doi: 10.1016/j.ijbiomac.2021.07.137.
30.Albert Gyapong Aduhene, Hongliang Cui, Hongyi Yang,Chengwei Liu, Guangchao Sui, Changli Liu. Poly(3-hydroxypropionate): Biosynthesis Pathways and Malonyl-CoA Biosensor Material Properties.Front Bioeng Biotechnol., doi: 10.3389/fbioe.2021.646995. 2021
31.类成智,韩海燕,刘成伟*,赵敏*
毛韧革菌次生代谢产物研究进展
《菌物学报》, 2021, 40 (8), 1918-1937. doi: 10.13346/j.mycosystema.210136
32.李恩楷,类成智,朱登轩,刘昱婷,刘成伟*.
阿特匹林C生物合成与活性研究进展
《海南医学》,2022,33(02):235-239.DOI：10.3969/j.issn.1003-6350.2022.02.027
2020年
33.Lei Gao, Cong Su, Xiaoxia Du, Ruishan Wang, Shuming Chen, Yu Zhou,Chengwei Liu, Xiaojing Liu, Runze Tian, Liyun Zhang, Kebo Xie, She Chen, Qianqian Guo, Lanping Guo, Yoshio Hano, Manabu Shimazaki, Atsushi Minami, Hideaki Oikawa, Niu Huang, K N Houk, Luqi Huang*, Jungui Dai*, Xiaoguang Lei*.
FAD-dependent Enzyme-Catalysed Intermolecular [4+2] Cycloaddition in Natural Product Biosynthesis.Nat Chem., 2020, doi: 10.1038/s41557-020-0467-7.
34.Yulu Jiang, Taro Ozaki, Mei Harada, Tadachika Miyasaka, Hajime Sato, Kazunori Miyamoto, Junichiro Kanazawa,Chengwei Liu, Jun-Ichi Maruyama, Masaatsu Adachi, Atsuo Nakazaki, Toshio Nishikawa, Masanobu Uchiyama, Atsushi Minami, Hideaki Oikawa*.
Biosynthesis of Indole Diterpene Lolitrems: Radical-Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton.Angew Chem Int Ed Engl.,2020, 59 (41), 17996-18002. DOI: 10.1002/anie.202007280
35.Tetsuya Shiina, Taro Ozaki, Yusuke Matsu, Shota Nagamine,Chengwei Liu, Masaru Hashimoto, Atsushi Minami, Hideaki Oikawa*.
Oxidative Ring Contraction by a Multifunctional Dioxygenase Generates the Core Cycloocatadiene in the Biosynthesis of Fungal Dimeric Anhydride Zopfiellin.Org Lett.,22(5),1997-2001, 2020. DOI: 10.1021/acs.orglett.0c00340
36.Takahiro Ugai, Atsushi Minami，Shizuya Tanaka，Taro Ozaki，Chengwei Liu，Hideyuki Shigemori，Masaru Hashimoto, Hideaki Oikawa*.
Biosynthetic machinery of 6‐hydroxymellein derivatives leading to cyclohelminthols and palmaenones.ChemBioChem.21 (3), 360-367,2020. doi: 10.1002/cbic.201900404.
37.Chengwei Liu, Atsushi Minami, Taro Ozaki, and Hideaki Oikawa
Biosynthesis of indole diterpenes.Comprehensive Natural Products III: Chemistry and Biology.2020, vol. 2, pp. 446-466.DOI:10.1016/b978-0-12-409547-2.14685-2.
2019年
38.Chengwei Liu, Atsushi Minami, Taro Ozaki, Jing Wu, Hirokazu Kawagishi, Jun-ichi Maruyama, Hideaki Oikawa*.
Efficient reconstitution of Basidiomycota diterpene erinacine gene cluster in Ascomycota hostAspergillus oryzaebased on genomic DNA sequences.J.Am. Chem. Soc.,141 (39), 15519-15523,2019. doi: 10.1021/jacs.9b08935.
39.Shota Nagamine,Chengwei Liu, Jumpei Nishishita, Takuto Kozaki, Kaho Sogahata, Yoshiro Sato, Atsushi Minami, Taro Ozaki, Claudia Schmidt-Dannert, Jun-ichi Maruyama, Hideaki Oikawa*.
Ascomycota Aspergillus oryzae is an efficient expression host for production of Basidiomycota terpenes using genomic DNA sequences.Appl Environ Microbiol.,85 (15), e00409-19, 2019. DOI: 10.1128/AEM.00409-19
40.Junya Takino, Takuto Kozaki, Taro Ozaki,Chengwei Liu, Atsushi Minami, Hideaki Oikawa*.
Elucidation of biosynthetic pathway of a plant hormone abscisic acid in phytopathogenic fungi.Biosci. Biotech. Biochem.83 (9), 1642-1649, 2019. DOI:10.1080/09168451.2019.1618700.
41.Ying Ye, Taro Ozaki, Myco Umemura,Chengwei Liu, Atsushi Minamia, Hideaki Oikawa*.
Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase.Org Biomol Chem., 17(1), 39-43, 2019. DOI: 10.1039/c8ob02824a
42.Tetsuya Shiina, Kazuya Nakagawa, Yukiko Fujisaki, Taro Ozaki,Chengwei Liu, Tomonobu Toyomasu, Masaru Hashimoto, Hiroyuki Koshino, Atsushi Minami, Hiroshi Kawaide & Hideaki Oikawa*.
Biosynthetic study of conidiation-inducing factor conidiogenone: heterologous production and cyclization mechanism of a key bifunctional diterpene synthase.Biosci Biotechnol Biochem.83 (2), 192-201,2019. DOI: 10.1080/09168451.2018.1536518
43.南篤志,尾崎太郎,劉成偉,及川英秋*.
糸状菌による植物ホルモンアブシジン酸の生合成・新奇な環化酵素の発見.バイオサイエンスとインダストリー,77(2), 136-138, 2019.
2018年
44.Atsushi Minami*, Taro Ozaki,Chengwei Liu, Hideaki Oikawa*.
Cyclopentane-forming di/sesterterpene synthases: widely distributed enzymes in bacteria, fungi, and plants.Nat Prod Rep. 35 (12), 1330-1346, 2018. DOI: 10.1039/c8np00026c.
45.Junya Takino, Takuto Kozaki, Yoshiro Sato,Chengwei Liu, Taro Ozaki, Atsushi Minami*, Hideaki Oikawa*.
Unveiling Biosynthesis of the Phytohormone Abscisic Acid in Fungi: Unprecedented Mechanism of Core Scaffold Formation Catalyzed by an Unusual Sesquiterpene Synthase.J. Am. Chem. Soc.,140 (39), 12392-12395, 2018. DOI: 10.1021/jacs.8b08925
46.Akihiro Tazawa, Ying Ye, Taro Ozaki,Chengwei Liu, Yasushi Ogasawara, Tohru Dairi, Yusuke Higuchi, Nobuo Kato, Katsuya Gomi, Atsushi Minami, and Hideaki Oikawa*.
Total Biosynthesis of Brassicicenes: Identification of a Key Enzyme for Skeletal Diversification.Org. Lett.20 (19), 6178-6182, 2018. DOI: 10.1021/acs.orglett.8b02654
47.Kosei Kudo,Chengwei Liu, Tomoyuki Matsumoto, Atsushi Minami, Taro Ozaki, Hiroaki Toshima, Katsuya Gomi, Hideaki Oikawa*.
Heterologous biosynthesis of fungal indole sesquiterpene sespendole.Chembiochem.19 (14), 1492-1497, 2018. DOI: 10.1002/cbic.201800187
48.Taro Ozaki, Sandip S. Shinde, Lei Gao, Ryo Okuizumi,Chengwei Liu,Yasushi Ogasawara, Xiaoguang Lei, Tohru Dairi, Atsushi Minami, Hideaki Oikawa*.
Enzymatic formation of a skipped methyl‐substituted octaprenyl side chain of longestin (KS‐505a): Involvement of homo‐IPP as a common extender unit.Angew. Chem. Int. Ed. Engl.57 (22), 6629-6632,2018. DOI: 10.1002/anie.201802116
49.Koji Narita, Atsushi Minami, Taro Ozaki,Chengwei Liu, Motoichiro Kodama, Hideaki Oikawa*.
Total Biosynthesis of Antiangiogenic Agent (−)-Terpestacin by Artificial Reconstitution of the Biosynthetic Machinery inAspergillus oryzae.J. Org. Chem.83(13), 7042-7048. 2018. DOI: 10.1021/acs.joc.7b03220
50.Lei Gao, Koji Narita, Taro Ozaki, Naoyoshi Kumakura, Pamela Gan, Atsushi Minami,Chengwei Liu, Xiaoguang Lei, Ken Shirasu, Hideaki Oikawa*.
Identification of novel sesterterpenes by genome mining of phytopathogenic fungiPhomaandColletotrichumsp.
Tetrahedron Letters. 59 (12), 1136-1139, 2018. https://doi.org/10.1016/j.tetlet.2018.02.022
51.南篤志,尾崎太郎,劉成偉,及川英秋*.
糸状菌テルペン環化酵素遺伝子のゲノムマイニングによる新規天然物の生産.バイオサイエンスとインダストリー,76(1), 20-25, 2018.
52.南篤志,劉成偉,尾﨑太郎,及川英秋.
酵母菌・麹菌・乳酸菌の産業応用展開(分担执笔部分:麹菌を宿主としたカビの二次代謝化合物の生産).シーエムシー出版社, 2018年1月.
2017年以前
53.Momoka Yamane, Atsushi Minami,Chengwei Liu, Taro Ozaki, Ichiro Takeuchi, Tae Tsukagoshi, Tetsuo Tokiwano, Katsuya Gomi, Hideaki Oikawa*.
Biosynthetic machinery of diterpene pleuromutilin isolated from basidiomycete fungi.Chembiochem. 18 (23), 2317-2322, 2017.DOI: 10.1002/cbic.201700434
54.Koji Narita, Hajime Sato, Atsushi Minami, Kosei Kudo, Lei Gao,Chengwei Liu, (他8人).
Focused Genome Mining of Structurally Related Sesterterpenes: Enzymatic Formation of Enantiomeric and Diastereomeric Products.Org. Lett. 19 (24), 6696–6699, 2017. DOI: 10.1021/acs.orglett.7b03418.
55.Chengwei Liu, Atsushi Minami, Tohru Dairi, Katsuya Gomi, Barry Scott, Hideaki Oikawa*.
Biosynthesis of Shearinine: Diversification of a Tandem Prenyl Moiety of Fungal Indole Diterpenes.Org. Lett.18 (19), 5026-5029, 2016. DOI: 10.1021/acs.orglett.6b02482.
56.Atsushi Minami,Chengwei Liu, Hideaki Oikawa*.
Total Biosynthesis of Fungal Indole Diterpenes Using Cell Factories.Heterocycles.92 (3), 397-421, 2016.DOI:10.1002/CHIN.201617243
57.Chengwei Liu, Koichi Tagami, Atsushi Minami, Tomoyuki Matsumoto, Jens Christian Frisvad, Hideyuki Suuki, Jun Ishikawa, Katsuya Gomi, Hideaki Oikawa*.
Reconstitution of Biosynthetic Machinery for the Synthesis of the Highly Elaborated Indole Diterpene Penitrem.Angew. Chem. Int. Ed. Engl. 54 (19), 5748-52, 2015. DOI: 10.1002/anie.201501072.
58.Ying Ye, Atsushi Minami, Attila Mandi,Chengwei Liu, Tohru Taniguchi, Tomohisa Kuzuyama, Kenji Monde, Katsuya Gomi, and Hideaki Oikawa*. Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes.J. Am. Chem. Soc.137(36), 11846-53, 2015. DOI: 10.1021/jacs.5b08319
59.南篤志,劉成偉,及川英秋*.
麹菌異種発現系を利用した糸状菌由来天然物の生産.
バイオサイエンスとインダストリー,73(6), 467-470, 2015.
60.Chengwei Liu, Motoyoshi Noike, Atsushi Minami, Hideaki Oikawa, Tohru Dairi*. A fungal prenyltransferase catalyzes the regular di-prenylation at positions 20 and 21 of paxilline.Biosci. Biotechnol. Biochem.78 (4), 448-54, 2014. doi:10.1080/09168451.2014.882759.
61.Chengwei Liu, Motoyoshi Noike, Atsushi Minami, Hideaki Oikawa, Tohru Dairi*. Functional analysis of a prenyltransferase gene (paxD) in the paxilline biosynthetic gene cluster.Appl. Microbiol. Biotechnol.98 (1), 199-06, 2014. DOI:10.1007/s00253-013-4834-9.
62.Koichi Tagami, Atsushi Minami, Ryuya Fujii,Chengwei Liu, Mizuki Tanaka, Katsuya Gomi, Tohru Dairi, Hideaki Oikawa*.
Rapid Reconstitution of Biosynthetic Machinery for Fungal Metabolites in Aspergillus oryzae: Total Biosynthesis of Aflatrem.ChemBioChem.15(14), 2076-80, 2014.DOI: 10.1002/cbic.201402195.
63.Chengwei Liu, Atsushi Minami, Motoyoshi Noike, Hiroaki Toshima, Hideaki Oikawa, Tohru Dairi*.
Regiospecificities and prenylation mode specificities of the fungal indole diterpene prenyltransferases AtmD and PaxD.Appl. Environ. Microbiol.79 (23), 7298-304, 2013. doi: 10.1128/AEM.02496-13.
64.Chengwei Liu, Tatsuya Fukumoto, Tadashi Matsumoto, Patrizia Gena, Daniele Frascaria, Tomoyuki Kaneko, Maki Katsuhara, Shihua Zhong, Xiaoli Sun, Yanming Zhu, Ikuko Iwasaki, Xiaodong Ding, Giuseppe Calamita*, Yoshichika Kitagawa*. Aquaporin OsPIP1;1 promotes rice salt resistance and seed germination.Plant. Physiol. Biochem.63, 151-158, 2013. doi: 10.1016/j.plaphy.2012.11.018.
65.Koichi Tagami,Chengwei Liu, Atsushi Minami, Motoyoshi Noike, Tetsuya Isaka, Shuhei Fueki, Yoshihiro Shichijo, Hiroaki Toshima , Katsuya Gomi, Tohru Dairi, Hideaki Oikawa*.
Reconstitution of Biosynthetic Machinery for Indole-Diterpene Paxilline inAspergillus oryzae.J. Am. Chem. Soc.135 (4), 1260–63, 2013. DOI: 10.1021/ja3116636
66.Xiaodong Ding, Tadashi Matsumoto, Patrizia Gena,Chengwei Liu, Marialuisa Pellegrini-Calace, Shihua Zhong, Xiaoli Sun, Yanming Zhu, Maki Katsuhara, Ikuko Iwasaki, Yoshichika Kitagawa, Giuseppe Calamita*. Water and CO₂permeability of SsAqpZ, the cyanobacterium Synechococcus sp. PCC7942 aquaporin.Biol. Cell.105 (3), 118-128, 2013. DOI: 10.1111/boc.201200057
67.Motoyoshi Noike,Chengwei Liu, Yusuke Ono, Yoshimitsu Hamano, Tomonobu Toyomasu, Takeshi Sassa, Nobuo Kato, Tohru Dairi*. An Enzyme Catalyzing O-Prenylation of the Glucose Moiety of Fusicoccin A, a Diterpene Glucoside Produced by the FungusPhomopsis amygdali.ChemBioChem.13 (4), 566-73, 2012. DOI: 10.1002/cbic.201100725.
68.Yoshichika Kitagawa*,Chengwei Liu, Xiaodong Ding*.
The influence of natural mineral water on aquaporin water permeability and human natural killer cell activity.Biochem. Biophys. Res. Commun.409 (1), 40-5, 2011. DOI: 10.1016/j.bbrc.2011.04.102
69.劉成偉,松本直，岩崎郁子，北川良親*.
アクアポリンの水透過性と植物のストレス耐性に対する日田天領水の作用.Food Style.13 (1), 92-97, 2009.
70.Tadashi Matsumoto, Hong-Li Lian, Wei-Ai Su, Daisuke Tanaka,Chengwei Liu, Ikuko Iwasaki, Yoshichika Kitagawa*.
Role of the aquaporin PIP1 subfamily in the chilling tolerance of rice.Plant. Cell. Physiol.50 (2), 216-29, 2009. DOI: 10.1093/pcp/pcn190.
